I'm ashamed to say I've used one once. I was in a very dark place and took all my mixed doses at once. I didnt care if it killed me and I hoped it would. I got a phone call that changed everything. So I dug it out and used it the last week of its shelf life. It worked and counteracted the opiods. I refused to go to the ER. I was so ashamed I was so weak when so many are strong. I just went back to bed and hoped I woke up.